An epidemiologic study on urothelial carcinomas of bladder

Bladder: Urothelial carcinomas

Immunoexpression of transcription factors in urothelial bladder carcinomas.

Transcription factors play a central role in the epithelial-mesenchymal transition (EMT), which is one of the biomolecular mechanisms involved in the progression of urothelial carcinomas of the bladder (UCB). In this study, we analyzed the immunoexpression of Twist 1, Snail, Slug and β-catenin in relation to histopathological prognostic parameters of UCB. The obtained results indicated the asso...

IMP3 expression in urothelial carcinomas of the urinary bladder.

OBJECTIVE Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas of the bladder. While the behavior of these superficial urothelial cancers is relatively benign, invasive tumors have a significant mortality rate. However, Ta and T1 tumors might display different biological behavior. There is therefore a great need for biomarkers that can accurately distinguish the beh...

Dietary Acid Load and Bladder Cancer Risk: An Epidemiologic Case-Control Study

Introduction: Dietary acid load contributes to metabolic acidosis, closely linked to cancer development through inflammation and cell transformation. There is very limited epidemiologic evidence; linking diet-dependent acid load and cancer risk. Since there are few published studies specifically on urinary pH and bladder cancer (BC) risk, we sought to explore this association in the present stud...

Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens.

AIMS To assess the prognostic significance of apoptosis related markers in bladder cancer. METHODS A tissue microarray containing 179 bladder carcinomas from cystectomy specimens was analysed immunohistochemically for active caspase-3, single-stranded DNA (ssDNA), p53, Bcl-2, Bax, and COX-2, in correlation to clinicopathological factors. RESULTS Active caspase-3, ssDNA, p53, Bax and COX-2 w...